Article
CYP2D6 mRNA expression in circulating peripheral blood mononuclear cells correlates with in vivo debrisoquine hydroxylase activity in extensive metabolizers.
Research communications in molecular pathology and pharmacology - 1 Feb 1996
Carcillo J A, Parise R A, Adedoyin A, Frye R, Branch R A, Romkes M
Abstract excerpt
Extensive metabolizers of drugs which are oxidized by cytochrome P450s show wide interindividual variability in drug metabolism. Elucidation of the relationship between specific P450 isozyme mRNA expression and variability in metabolism of specific drugs could improve understanding of the molecul...
Topics
- Actins
- Adult
- Aged
- Cytochrome P-450 CYP2D6
- Female
- Gene Expression Regulation, Enzymologic
- Genotype
- Humans
- Male
- Middle Aged
- Monocytes
- Neoplasms
- Phenotype
- Polymerase Chain Reaction
- RNA, Messenger