Article
Debrisoquine hydroxylation phenotypes of patients with high versus low to normal serum antidepressant concentrations.
Journal of clinical psychopharmacology - 1 Aug 1992
Tacke U, Leinonen E, Lillsunde P, Seppälä T, Arvela P, Pelkonen O, Ylitalo P
Abstract excerpt
Debrisoquine hydroxylation phenotype was determined in 22 psychiatric patients who had previously developed exceptionally high serum antidepressant (AD) concentrations, and in 22 sex-, age-, and dose-matched counterparts who had low to normal serum AD levels. The patients were recruited from 641...
Topics
- Antidepressive Agents
- Chromatography, Gas
- Cytochrome P-450 Enzyme System
- Debrisoquin
- Depressive Disorder
- Female
- Humans
- Hydroxylation
- Male
- Phenotype
- Prevalence