A PET study of D2 and 5-HT2 receptor occupancy induced by risperidone in poor metabolizers of debrisoquin and risperidone.

doi:10.1007/BF02246302

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Article

A PET study of D2 and 5-HT2 receptor occupancy induced by risperidone in poor metabolizers of debrisoquin and risperidone.

Psychopharmacology - 1 Jun 1995

Nyberg S, Dahl M L, Halldin C

Abstract excerpt

The hydroxylation of the new antipsychotic drug risperidone to its main, active metabolite 9-hydroxyrisperidone is catalyzed by the hepatic cytochrome P450 enzyme CYP2D6, and cosegregates with the polymorphic hydroxylation of debrisoquin. We have previously examined central D2 dopamine and 5-HT2...

Topics

Adult
Antipsychotic Agents
Debrisoquin
Genotype
Humans
Isoxazoles
Male
Piperidines
Receptors, Dopamine
Receptors, Serotonin
Risperidone
Tomography, Emission-Computed

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