Article
Natural resistance to intracellular infections: Nramp1 encodes a membrane phosphoglycoprotein absent in macrophages from susceptible (Nramp1 D169) mouse strains.
Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 1996
Vidal S M, Pinner E, Lepage P, Gauthier S, Gros P
Abstract excerpt
The mouse Nramp1 gene (Bcg/Ity/Lsh) controls innate defense to infection with intracellular parasites such as Mycobacterium, Salmonella, and Leishmania. Sequence analysis of Nramp1 predicts a hydrophobic, membrane-associated protein expressed exclusively in monocyte/macrophage lineages. A single...
Topics
- Amino Acid Sequence
- Animals
- Antibodies
- Base Sequence
- Carrier Proteins
- Cation Transport Proteins
- DNA, Complementary
- Genes, myc
- Glycosylation
- Immunity, Innate
- Immunization
- Leishmania
- Macrophages, Peritoneal
- Membrane Proteins
- Mice
- Mice, Inbred Strains
- Molecular Sequence Data
- Mutation