Article
Clonally diverse CTL response to a dominant viral epitope recognizes potential epitope variants.
Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 2001
Charini W A, Kuroda M J, Schmitz J E, Beaudry K R, Lin W, Lifton M A, Krivulka G R, Necker A, Letvin N L
Abstract excerpt
RNA viruses undergo rapid sequence variation as the result of error-prone RNA replication mechanisms. When viable mutations arise in RNA regions encoding B or T cell epitopes, mutant viruses that can evade immune detection may be selected. In the carefully studied CTL response to the Gag p11C(C-M) epitope in SIVmac-infected Mamu-A*01(+) rhesus monkeys, it has been shown that CTL recognition of that epitope can...
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