Contribution of CD8+ T cells to containment of viral replication and emergence of mutations in Mamu-A*01-restricted epitopes in Simian immunodeficiency virus-infected rhesus monkeys.

Abstract excerpt

Here, we investigated the containment of virus replication in simian immunodeficiency virus (SIV) infection by CD8(+) lymphocytes. Escape mutations in Mamu-A*01 epitopes appeared first in SIV Tat TL8 and then in SIV Gag p11C. The appearance of escape mutations in SIV Gag p11C was coincident with compensatory changes outside of the epitope. Eliminating CD8(+) lymphocytes from rhesus monkeys during primary...

Topics

• Animals
• CD8-Positive T-Lymphocytes
• Epitopes, T-Lymphocyte
• Gene Products, gag
• Gene Products, tat
• Histocompatibility Antigens Class I
• Macaca mulatta
• Mutation
• Simian Acquired Immunodeficiency Syndrome