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Article

Immunodomination in the evolution of dominant epitope-specific CD8+ T lymphocyte responses in simian immunodeficiency virus-infected rhesus monkeys.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jan 2006

Newberg Michael H, McEvers Kimberly J, Gorgone Darci A, Lifton Michelle A, Baumeister Susanne H C, Veazey Ronald S, Schmitz Jörn E, Letvin Norman L

Abstract excerpt

Because the control of HIV-1 replication is largely dependent on CD8+ T lymphocyte responses specific for immunodominant viral epitopes, vaccine strategies that increase the breadth of dominant epitope-specific responses should contribute to containing HIV-1 spread. Developing strategies to elicit such broad immune responses will require an understanding of the mechanisms responsible for focusing CD8+ T...

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Share to Antigens, Viral
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Histocompatibility Antigens Class I

Share to Immunodominant Epitopes

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Share to Simian Acquired Immunodeficiency Syndrome

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Source

Identifiers

PMID: 16365424
DOI: 10.4049/jimmunol.176.1.319

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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