Article
Expansion after epitope peptide exposure in vitro predicts cytotoxic T lymphocyte epitope dominance hierarchy in lymphocytes of vaccinated mamu-a*01+ rhesus monkeys.
AIDS research and human retroviruses - 1 May 2006
Subbramanian Ramu A, Charini William A, Kuroda Marcelo J, Seaman Michael, Chhay Heng, Lifton Michelle A, Gorgone Darci A, Schmitz Jörn E, Carville Angela, Letvin Norman L
Abstract excerpt
Because of the importance of developing HIV vaccine strategies that generate cytotoxic T lymphocyte (CTL) responses with a maximal breadth of epitope recognition, we have explored a variety of novel strategies designed to overcome the usual propensity of CTLs to focus recognition on a limited number of dominant epitopes. In studies of rhesus monkeys expressing the Mamu-A*01 MHC class I allele, we show that...
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