Article
Cytotoxic T lymphocytes do not appear to select for mutations in an immunodominant epitope of simian immunodeficiency virus gag.
Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 1992
Chen Z W, Shen L, Miller M D, Ghim S H, Hughes A L, Letvin N L
Abstract excerpt
Studies to date assessing HIV escape from CTL in vivo have yielded conflicting results. Previous studies have demonstrated that simian immunodeficiency virus of macaques (SIVmac)-infected rhesus monkeys expressing the MHC class I allele Mamu-A*01 reproducibly develop a gag-specific CTL response limited to a 9-amino acid epitope of the SIVmac gag protein (residues 182-190 within peptide 11C). To determine whether...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cell Line
- Cytotoxicity, Immunologic
- Gene Products, gag
- Immunity, Cellular
- Immunodominant Epitopes
- Macaca mulatta
- Molecular Sequence Data