Article
Infection with "escaped" virus variants impairs control of simian immunodeficiency virus SIVmac239 replication in Mamu-B*08-positive macaques.
Journal of virology - 1 Nov 2009
Valentine Laura E, Loffredo John T, Bean Alex T, León Enrique J, MacNair Caitlin E, Beal Dominic R, Piaskowski Shari M, Klimentidis Yann C, Lank Simon M, Wiseman Roger W, Weinfurter Jason T, May Gemma E, Rakasz Eva G, Wilson Nancy A, Friedrich Thomas C, O'Connor David H, Allison David B, Watkins David I
Abstract excerpt
An understanding of the mechanism(s) by which some individuals spontaneously control human immunodeficiency virus (HIV)/simian immunodeficiency virus replication may aid vaccine design. Approximately 50% of Indian rhesus macaques that express the major histocompatibility complex (MHC) class I allele Mamu-B*08 become elite controllers after infection with simian immunodeficiency virus SIVmac239. Mamu-B*08 has a...
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