Article
Mauritian cynomolgus macaques share two exceptionally common major histocompatibility complex class I alleles that restrict simian immunodeficiency virus-specific CD8+ T cells.
Journal of virology - 1 Jun 2009
Burwitz Benjamin J, Pendley Chad J, Greene Justin M, Detmer Ann M, Lhost Jennifer J, Karl Julie A, Piaskowski Shari M, Rudersdorf Richard A, Wallace Lyle T, Bimber Benjamin N, Loffredo John T, Cox Daryl G, Bardet Wilfried, Hildebrand William, Wiseman Roger W, O'Connor Shelby L, O'Connor David H
Abstract excerpt
Vaccines that elicit CD8(+) T-cell responses are routinely tested for immunogenicity in nonhuman primates before advancement to clinical trials. Unfortunately, the magnitude and specificity of vaccine-elicited T-cell responses are variable in currently utilized nonhuman primate populations, owing...
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