Article
E2F repression by C/EBPalpha is required for adipogenesis and granulopoiesis in vivo.
Cell - 19 Oct 2001
Porse B T, Pedersen TA, Xu X, Lindberg B, Wewer U M, Friis-Hansen L, Nerlov C
Abstract excerpt
The C/EBPalpha transcription factor is required for differentiation of adipocytes and neutrophil granulocytes, and controls cellular proliferation in vivo. To address the molecular mechanisms of C/EBPalpha action, we have identified C/EBPalpha mutants defective in repression of E2F-dependent transcription and found them to be impaired in their ability to suppress cellular proliferation, and to induce adipocyte...
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