Article
Linkage and association of CYP17 gene in hereditary and sporadic prostate cancer.
International journal of cancer - 20 Nov 2001
Chang B, Zheng S L, Isaacs S D, Wiley K E, Carpten J D, Hawkins G A, Bleecker E R, Walsh P C, Trent J M, Meyers D A, Isaacs W B, Xu J
Abstract excerpt
Androgens are essential for prostate development, growth and maintenance and the association between androgen levels and prostate cancer is well established. Since the CYP17 gene encodes the enzyme cytochrome P450c17alpha, which mediates 17alpha-hydroxylase and 17,20-lyase activities in the androgen biosynthesis pathway, sequence variations in the gene and association with increased risk to prostate cancer has...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.