Article
Polymorphic GGC repeats in the androgen receptor gene are associated with hereditary and sporadic prostate cancer risk.
Human genetics - 1 Feb 2002
Chang Bao-li, Zheng Siqun L, Hawkins Gregory A, Isaacs Sarah D, Wiley Kathy E, Turner Aubrey, Carpten John D, Bleecker Eugene R, Walsh Patrick C, Trent Jeffrey M, Meyers Deborah A, Isaacs William B, Xu Jianfeng
Abstract excerpt
Androgen receptor (AR) has long been hypothesized to play an important role in prostate cancer etiology. Two trinucleotide repeat polymorphisms (CAG and GGC repeats in exon 1 of the AR gene) have been investigated as risk factors for prostate cancer in several studies. However, the results are inconclusive, probably because of the variations of study designs, characteristics of study samples, and choices of...
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