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Article

Role of RAD51 in sister-chromatid exchanges in mammalian cells.

Oncogene - 4 Oct 2001

Lambert S, Lopez B S

Abstract excerpt

To measure the impact of the RAD51 pathway on Sister-Chromatid Exchanges (SCE), we used hamster cells expressing either the wild-type MmRAD51, which stimulates, or the dominant negative SMRAD51, which inhibits, gene conversion without affecting cell viability of untreated as well as gamma-rays irradiated cells. We show that MmRAD51 did not affect the rate of spontaneous SCE while it strongly stimulated...

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Source

Identifiers

PMID: 11641788
DOI: 10.1038/sj.onc.1204813

Genes

RAD51

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Role of RAD51 in sister-chromatid exchanges in mammalian cells.PMID 11641788Read ↗

Overexpression of mammalian Rad51 does not stimulate tumorigenesis while a dominant-negative Rad51 affects centrosome fragmentation, ploidy and stimulates tumorigenesis, in p53-defective CHO cells.Semantic proximity Read ↗

RAD51 protects against nonconservative DNA double-strand break repair through a nonenzymatic functionSemantic proximity Read ↗

Spontaneous and double-strand break-induced recombination, and gene conversion tract lengths, are differentially affected by overexpression of wild-type or ATPase-defective yeast Rad54.Semantic proximity Read ↗

XRCC2 and XRCC3 regulate the balance between short- and long-tract gene conversions between sister chromatids.Semantic proximity Read ↗

Mouse RAD54 affects DNA double-strand break repair and sister chromatid exchange.Semantic proximity Read ↗

The ERCC1/XPF endonuclease is required for efficient single-strand annealing and gene conversion in mammalian cellsSemantic proximity Read ↗

Role of mammalian RAD51L2 (RAD51C) in recombination and genetic stability.Semantic proximity Read ↗

Overexpression of Rad51 inhibits double-strand break-induced homologous recombination but does not affect gene conversion tract lengths.Semantic proximity Read ↗

Rad51C is essential for embryonic development and haploinsufficiency causes increased DNA damage sensitivity and genomic instability.Semantic proximity Read ↗

Spontaneous homologous recombination is induced by collapsed replication forks that are caused by endogenous DNA single-strand breaks.Semantic proximity Read ↗

Homologous and homeologous intermolecular gene conversion are not differentially affected by mutations in the DNA damage or the mismatch repair genes RAD1, RAD50, RAD51, RAD52, RAD54, PMS1 and MSH2.Semantic proximity Read ↗

Chromosomal double-strand breaks induce gene conversion at high frequency in mammalian cells.Semantic proximity Read ↗

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