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Article

RAD51 protects against nonconservative DNA double-strand break repair through a nonenzymatic function

25 Jan 2022

Abstract excerpt

Selection of the appropriate DNA double-strand break (DSB) repair pathway is decisive for genetic stability. It is proposed to act according to two steps: 1-canonical nonhomologous end-joining (C-NHEJ) versus resection that generates single-stranded DNA (ssDNA) stretches; 2-on ssDNA, gene conversion (GC) versus nonconservative single-strand annealing (SSA) or alternative end-joining (A-EJ). Here, we addressed the...

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PMID: 35137208
DOI: 10.1093/nar/gkac073

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