Article
Role of mammalian RAD51L2 (RAD51C) in recombination and genetic stability.
The Journal of biological chemistry - 31 May 2002
French Catherine A, Masson Jean-Yves, Griffin Carol S, O'Regan Paul, West Stephen C, Thacker John
Abstract excerpt
The highly conserved RAD51 protein has a central role in homologous recombination. Five novel RAD51-like genes have been identified in mammalian cells, but little is known about their functions. A DNA damage-sensitive hamster cell line, irs3, was found to have a mutation in the RAD51L2 gene and an undetectable level of RAD51L2 protein. Resistance of irs3 to DNA-damaging agents was significantly increased by...
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