DICER1: mutations, microRNAs and mechanisms.

doi:10.1038/nrc3802

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Article

DICER1: mutations, microRNAs and mechanisms.

Nature reviews. Cancer - 1 Oct 2014

Foulkes William D, Priest John R, Duchaine Thomas F

Abstract excerpt

Dicer is central to microRNA-mediated silencing and several other RNA interference phenomena that are profoundly embedded in cancer gene networks. Most recently, both germline and somatic mutations in DICER1 have been identified in diverse types of cancer. Although some of the mutations clearly reduce the dosage of this key enzyme, others dictate surprisingly specific changes in select classes of small RNAs. This...

Topics

Animals
DEAD-box RNA Helicases
Genetic Predisposition to Disease
Humans
MicroRNAs
Mutation
Neoplasms
Protein Structure, Tertiary
RNA Interference
Ribonuclease III

Source

Open in PubMed

Identifiers

PMID: 25176334
DOI: 10.1038/nrc3802

Genes

DICER1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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