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Article

Distinct roles for RDE-1 and RDE-4 during RNA interference in Caenorhabditis elegans.

RNA (New York, N.Y.) - 1 Oct 2001

Parrish S, Fire A

Abstract excerpt

RNA interference (RNAi) is a cellular defense mechanism that uses double-stranded RNA (dsRNA) as a sequence-specific trigger to guide the degradation of homologous single-stranded RNAs. RNAi is a multistep process involving several proteins and at least one type of RNA intermediate, a population of small 21-25 nt RNAs (called siRNAs) that are initially derived from cleavage of the dsRNA trigger. Genetic screens...

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PMID: 11680844
PMCID: PMC1370183

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