Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Direct estimate of the mutation rate and the distribution of fitness effects in the yeast Saccharomyces cerevisiae.

Genetics - 1 Oct 2001

Wloch D M, Szafraniec K, Borts R H, Korona R

Abstract excerpt

Estimates of the rate and frequency distribution of deleterious effects were obtained for the first time by direct scoring and characterization of individual mutations. This was achieved by applying tetrad analysis to a large number of yeast clones. The genomic rate of spontaneous mutation deleterious to a basic fitness-related trait, that of growth rate, was U = 1.1 x 10(-3) per diploid cell division....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ethyl Methanesulfonate
Share to Mutagens
Share to Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phenotype

Share to Saccharomyces cerevisiae

Source

Open in PubMed Open full text

Identifiers

PMID: 11606524
DOI: 10.1093/genetics/159.2.441
PMCID: PMC1461830

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Direct estimate of the mutation rate and the distribution of fitness effects in the yeast Saccharomyces cerevisiae.PMID 11606524Read ↗

Estimates of the rate and distribution of fitness effects of spontaneous mutation in Saccharomyces cerevisiae.Semantic proximity Read ↗

Spontaneous mutations in diploid Saccharomyces cerevisiae: more beneficial than expected.Semantic proximity Read ↗

Experimental studies of deleterious mutation in Saccharomyces cerevisiae.Semantic proximity Read ↗

Spontaneous mutations in diploid Saccharomyces cerevisiae: another thousand cell generations.Semantic proximity Read ↗

Mutational load and the transition between diploidy and haploidy in experimental populations of the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

DNA sequence analysis of spontaneous mutagenesis in Saccharomyces cerevisiae.Semantic proximity Read ↗

Schrödinger's yeast: the challenge of using transformation to compare fitness among Saccharomyces cerevisiae that differ in ploidy or zygosity.Semantic proximity Read ↗

Mutations in yeast are deleterious on average regardless of the degree of adaptation to the testing environment.Semantic proximity Read ↗

The fitness effects of spontaneous mutations in Caenorhabditis elegans.Semantic proximity Read ↗

Measuring spontaneous deleterious mutation process.Semantic proximity Read ↗

Genomic mutation rates for lifetime reproductive output and lifespan in Caenorhabditis elegans.Semantic proximity Read ↗

Small fitness effects and weak genetic interactions between deleterious mutations in heterozygous loci of the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.