Article
Small fitness effects and weak genetic interactions between deleterious mutations in heterozygous loci of the yeast Saccharomyces cerevisiae.
Genetical research - 1 Aug 2003
Szafraniec Krzysztof, Wloch Dominika M, Sliwa Piotr, Borts Rhona H, Korona Ryszard
Abstract excerpt
Rare, random mutations were induced in budding yeast by ethyl methanesulfonate (EMS). Clones known to bear a single non-neutral mutation were used to obtain mutant heterozygotes and mutant homozygotes that were later compared with wild-type homozygotes. The average homozygous effect of mutation was an approximately 2% decrease in the growth rate. In heterozygotes, the harmful effect of these relatively mild...
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