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Article

Selection of the same mutation in the U69 protein kinase gene of human herpesvirus-6 after prolonged exposure to ganciclovir in vitro and in vivo.

The Journal of general virology - 1 Nov 2001

Manichanh Chaysavanh, Olivier-Aubron Camille, Lagarde Jean-Pierre, Aubin Jean-Thierry, Bossi Phillipe, Gautheret-Dejean Agnès, Huraux Jean-Marie, Agut Henri

Abstract excerpt

After serial passage in the presence of increasing concentrations of ganciclovir (GCV) in vitro, a human herpesvirus-6 (HHV-6) mutant exhibiting a decreased sensitivity to the drug was isolated. Analysis of drug susceptibility showed that the IC(50) of this mutant was 24-, 52- and 3-fold higher than that of the wild-type (wt) IC(50) in the case of GCV, cidofovir and foscarnet, respectively. Genotypic analysis...

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Identifiers

PMID: 11602788
DOI: 10.1099/0022-1317-82-11-2767

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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