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Article

Selection and characterization of varicella-zoster virus variants resistant to (R)-9-[4-hydroxy-2-(hydroxymethy)butyl]guanine.

Antimicrobial agents and chemotherapy - 1 Jun 2001

Ng T I, Shi Y, Huffaker H J, Kati W, Liu Y, Chen C M, Lin Z, Maring C, Kohlbrenner W E, Molla A

Abstract excerpt

(R)-9-[4-Hydroxy-2-(hydroxymethy)butyl]guanine (H2G) is a potent and selective inhibitor of herpesvirus replication. It is a nucleoside analog, and its triphosphate derivative (H2G-TP) is a competitive inhibitor of herpesvirus DNA polymerases. In this study, the antiviral activities of H2G and ac...

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Identifiers

PMID: 11353604
DOI: 10.1128/AAC.45.6.1629-1636.2001
PMCID: PMC90524

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11353604-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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