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Article

Different mutations in the HHV-6 DNA polymerase gene accounting for resistance to foscarnet.

Antiviral therapy - 1 Jan 2007

Bonnafous Pascale, Naesens Lieve, Petrella Stéphanie, Gautheret-Dejean Agnès, Boutolleau David, Sougakoff Wladimir, Agut Henri

Abstract excerpt

BACKGROUND: Human herpesvirus 6 (HHV-6), which is closely related to human cytomegalovirus, is sensitive to foscarnet (PFA). Up to now, the resistance of HHV-6 to PFA has not been investigated. OBJECTIVES: The goal of the study was to isolate and characterize PFA-resistant HHV-6 mutants in order to determine the mechanisms of resistance to the drug. METHODS: PFA-resistant viruses, isolated in MT4 cell culture...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 17926642

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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