Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mapping ganciclovir resistance in the human herpesvirus-6 U69 protein kinase.

Journal of medical virology - 1 Nov 2003

Safronetz D, Petric M, Tellier R, Parvez B, Tipples G A

Abstract excerpt

Human herpesvirus-6 (HHV-6) is a growing concern in immunocompromised individuals, such as in the transplant setting. Alone, or in concert with human cytomegalovirus (HCMV), infections with HHV-6 are often severe enough to require antiviral therapy, generally in the form of ganciclovir (GCV). GCV resistance in HCMV is well documented, both clinically and in the laboratory, and has been shown to result from...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antiviral Agents
Share to Baculoviridae
Share to Drug Resistance, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ganciclovir

Share to Genetic Vectors

Share to Herpesvirus 6, Human

Share to Protein Kinases

Share to Spodoptera

Source

Identifiers

PMID: 12966551
DOI: 10.1002/jmv.10510

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mapping ganciclovir resistance in the human herpesvirus-6 U69 protein kinase.PMID 12966551Read ↗

Selection of the same mutation in the U69 protein kinase gene of human herpesvirus-6 after prolonged exposure to ganciclovir in vitro and in vivo.Semantic proximity Read ↗

Mutation in the UL97 open reading frame of human cytomegalovirus strains resistant to ganciclovirSemantic proximity Read ↗

Mutations in human cytomegalovirus UL97 gene confer clinical resistance to ganciclovir and can be detected directly in patient plasma.Semantic proximity Read ↗

Analysis of the UL97 phosphotransferase coding sequence in clinical cytomegalovirus isolates and identification of mutations conferring ganciclovir resistance.Semantic proximity Read ↗

Rapid detection by reverse hybridization of mutations in the UL97 gene of human cytomegalovirus conferring resistance to ganciclovir.Semantic proximity Read ↗

Cytomegalovirus UL97 mutations in the era of ganciclovir and maribavirSemantic proximity Read ↗

Recombinant phenotyping of cytomegalovirus UL97 kinase sequence variants for ganciclovir resistance.Semantic proximity Read ↗

Cytomegalovirus UL97 phosphotransferase mutations that affect susceptibility to ganciclovir.Semantic proximity Read ↗

Single and multiple mutations in the human cytomegalovirus UL97 gene and their relationship to the enzymatic activity of UL97 kinase for ganciclovir phosphorylation.Semantic proximity Read ↗

Early emergence of ganciclovir-resistant human cytomegalovirus strains in children with primary combined immunodeficiency.Semantic proximity Read ↗

Acyclovir is phosphorylated by the human cytomegalovirus UL97 protein.Semantic proximity Read ↗

Novel method based on "en passant" mutagenesis coupled with a gaussia luciferase reporter assay for studying the combined effects of human cytomegalovirus mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.