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Article

Characterization of herpes simplex virus type 1 thymidine kinase mutants selected under a single round of high-dose brivudin.

Journal of virology - 1 May 2005

Andrei Graciela, Balzarini Jan, Fiten Pierre, De Clercq Erik, Opdenakker Ghislain, Snoeck Robert

Abstract excerpt

A broad variety of herpes simplex virus type 1 clones was selected under a single round of high-dose selection with brivudin. Mutations in the thymidine kinase (TK) genes consisted of 42% frameshift mutations within homopolymer repeats of G's and C's and single nucleotide substitutions (58%) that produced stop codons (Q261 and R281) or a new codon at the site of the substitution (A168T, R51W, G59W, G206R, R220H,...

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Identifiers

PMID: 15827202
DOI: 10.1128/JVI.79.9.5863-5869.2005
PMCID: PMC1082774

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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