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PCR with quenching probes enables the rapid detection and identification of ganciclovir-resistance-causing U69 gene mutations in human herpesvirus 6.

Molecular and cellular probes - 1 Aug 2010

Isegawa Yuji, Matsumoto Chisa, Nishinaka Kazuko, Nakano Kazushi, Tanaka Tatsuya, Sugimoto Nakaba, Ohshima Atsushi

Abstract excerpt

A single-nucleotide polymorphism detection assay using PCR with quenching probes (QP-PCR) was developed for the rapid detection of antiviral drug-resistance mutations of human herpesvirus 6 (HHV-6). The mutations examined were in the HHV-6 U69 gene, and were single-base mutations in sequences known to be associated with ganciclovir (GCV) resistance in HCMV. We previously confirmed that they conferred GCV...

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PMID: 20083192
DOI: 10.1016/j.mcp.2010.01.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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