Article
Identification of the gene immediately downstream of the murine INK4a/ARF locus.
Experimental gerontology - 1 Aug 2001
Pantoja C, Palmero I, Serrano M
Abstract excerpt
The tumor suppressor gene ARF is formed by three exons, namely exons 1 beta, 2 and 3. Here, we show that embryo fibroblasts from mice genetically deficient in exons 2 and 3 (Delta 2,3) express a transcript formed by exon 1 beta followed by the 3'-terminal exon of the gene immediately downstream o...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cells, Cultured
- Chimera
- Chromosome Mapping
- Cyclin-Dependent Kinase Inhibitor p16
- DNA Primers
- DNA, Complementary
- Exons
- Gene Expression
- Genes, Tumor Suppressor
- Genes, p16
- Mice
- Mice, Knockout
- Molecular Sequence Data
- Mutation