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Modulation of the expression of p16<sup>INK4a</sup>and p14<sup>ARF</sup>by hnRNP A1 and A2 RNA binding proteins: Implications for cellular senescence

15 Aug 2002

Abstract excerpt

Cellular senescence is a terminal growth phase characteristic of normal human diploid fibroblasts. Altered gene expression during cellular senescence is numerous compared to that of younger proliferative cells in culture. We have previously reported that the levels and activities of hnRNP A1 and A2 RNA binding proteins are decreased in senescent human fibroblasts. Both proteins are multifunctional and may...

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PMID: 12209876
DOI: 10.1002/jcp.10147

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