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Article

MSH2 mutation carriers are at higher risk of cancer than MLH1 mutation carriers: a study of hereditary nonpolyposis colorectal cancer families.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 15 Oct 2001

Vasen H F, Stormorken A, Menko F H, Nagengast F M, Kleibeuker J H, Griffioen G, Taal B G, Moller P, Wijnen J T

Abstract excerpt

PURPOSE: Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant disease characterized by the clustering of colorectal cancer, endometrial cancer, and various other cancers. The disease is caused by mutations in DNA-mismatch-repair (MMR) genes, most frequently in MLH1, MSH2, and MSH6. The aims of the present study were to compare the risk of developing colorectal, endometrial, and other cancers...

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Identifiers

PMID: 11600610
DOI: 10.1200/JCO.2001.19.20.4074

Genes

MSH2
MLH1
MSH6

Provenance

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Source receipt: pubmed, retrieved 7 Sept 2026.

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MSH2 mutation carriers are at higher risk of cancer than MLH1 mutation carriers: a study of hereditary nonpolyposis colorectal cancer families.PMID 11600610Read ↗

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Cumulative incidence of colorectal and extracolonic cancers in MLH1 and MSH2 mutation carriers of hereditary nonpolyposis colorectal cancer.Semantic proximity Read ↗

Cancer-risk by family history and mismatch-repair mutation in Lynch syndrome.Semantic proximity Read ↗

Genotype-phenotype comparison of German MLH1 and MSH2 mutation carriers clinically affected with Lynch syndrome: a report by the German HNPCC Consortium.Semantic proximity Read ↗

Lower incidence of colorectal cancer and later age of disease onset in 27 families with pathogenic MSH6 germline mutations compared with families with MLH1 or MSH2 mutations: the German Hereditary Nonpolyposis Colorectal Cancer Consortium.Semantic proximity Read ↗

The genetics of HNPCC: application to diagnosis and screening.Semantic proximity Read ↗

Clustering of Lynch syndrome malignancies with no evidence for a role of DNA mismatch repair.Semantic proximity Read ↗

Colorectal and extracolonic cancer variations in MLH1/MSH2 hereditary nonpolyposis colorectal cancer kindreds and the general population.Semantic proximity Read ↗

Mutations predisposing to hereditary nonpolyposis colorectal cancer: database and results of a collaborative study. The International Collaborative Group on Hereditary Nonpolyposis Colorectal Cancer.Semantic proximity Read ↗

Review article: the Lynch syndrome (hereditary nonpolyposis colorectal cancer)*Semantic proximity Read ↗

Multigene Panel Testing Provides a New Perspective on Lynch Syndrome.Semantic proximity Read ↗

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