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Article

Multigene Panel Testing Provides a New Perspective on Lynch Syndrome.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Aug 2017

Espenschied Carin R, LaDuca Holly, Li Shuwei, McFarland Rachel, Gau Chia-Ling, Hampel Heather

Abstract excerpt

Purpose Most existing literature describes Lynch syndrome (LS) as a hereditary syndrome leading to high risks of colorectal cancer (CRC) and endometrial cancer mainly as a result of mutations in MLH1 and MSH2. Most of these studies were performed on cohorts with disease suggestive of hereditary CRC and population-based CRC and endometrial cancer cohorts, possibly biasing results. We aimed to describe a large...

Read the complete abstract on PubMed

Topics

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Share to Colorectal Neoplasms, Hereditary Nonpolyposis
Share to DNA Mismatch Repair

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epithelial Cell Adhesion Molecule

Share to Genes, BRCA1

Share to Genes, BRCA2

Share to Mismatch Repair Endonuclease PMS2

Share to MutL Protein Homolog 1

Share to MutS Homolog 2 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 28514183
DOI: 10.1200/JCO.2016.71.9260
PMCID: PMC7186580

Genes

BRCA1
MLH1
MSH2
MSH6
PMS2
EPCAM
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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