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Article

Clustering of Lynch syndrome malignancies with no evidence for a role of DNA mismatch repair.

Gynecologic oncology - 1 Feb 2008

Case Ashley S, Zighelboim Israel, Mutch David G, Babb Sheri A, Schmidt Amy P, Whelan Alison J, Thibodeau Stephen N, Goodfellow Paul J

Abstract excerpt

OBJECTIVES: We ascertained a large kindred with an excess of Lynch syndrome-associated cancers. Our objective was to determine if a defect in one of the DNA mismatch repair (DMMR) genes was the probable cause of cancer susceptibility as microsatellite instability (MSI) and immunohistochemical (IHC) analysis of the probands' tumors did not provide a clear indication. METHODS: A detailed history and review of...

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Topics

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Share to Adenosine Triphosphatases
Share to Colorectal Neoplasms, Hereditary Nonpolyposis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mismatch Repair Endonuclease PMS2

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Source

Open in PubMed Open full text

Identifiers

PMID: 18022218
DOI: 10.1016/j.ygyno.2007.09.036
PMCID: PMC3023170

Genes

MLH1
MSH2
MSH6
PMS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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