Cumulative incidence of colorectal and extracolonic cancers in MLH1 and MSH2 mutation carriers of hereditary nonpolyposis colorectal cancer.

doi:10.1016/s1091-255x(98)80105-4

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Article

Cumulative incidence of colorectal and extracolonic cancers in MLH1 and MSH2 mutation carriers of hereditary nonpolyposis colorectal cancer.

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract - 1 Jan 2000

Lin K M, Shashidharan M, Thorson A G, Ternent C A, Blatchford G J, Christensen M A, Watson P, Lemon S J, Franklin B, Karr B, Lynch J, Lynch H T

Abstract excerpt

The extracolonic tumor spectrum of hereditary nonpolyposis colorectal cancer (HNPCC) includes cancer of the endometrium, ovaries, stomach, biliary tract, and urinary tract. This study was designed to determine the penetrance of colorectal and extracolonic tumors in HNPCC mutation carriers. Forty-...

Topics

Adaptor Proteins, Signal Transducing
Adenosine Triphosphatases
Adult
Age Factors
Biliary Tract Neoplasms
Carrier Proteins
Colonic Neoplasms
Colorectal Neoplasms, Hereditary Nonpolyposis
DNA Repair
DNA-Binding Proteins
Endometrial Neoplasms
Female

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Follow-Up Studies

Genotype

Germ-Line Mutation

Heterozygote

Humans

Incidence

Source

Open in PubMed

Identifiers

PMID: 9841970
DOI: 10.1016/s1091-255x(98)80105-4

Genes

MSH2
MLH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9841970-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.