Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cumulative incidence of colorectal and extracolonic cancers in MLH1 and MSH2 mutation carriers of hereditary nonpolyposis colorectal cancer.

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract - 1 Jan 1998

Lin K M, Shashidharan M, Thorson A G, Ternent C A, Blatchford G J, Christensen M A, Watson P, Lemon S J, Franklin B, Karr B, Lynch J, Lynch H T

Abstract excerpt

The extracolonic tumor spectrum of hereditary nonpolyposis colorectal cancer (HNPCC) includes cancer of the endometrium, ovaries, stomach, biliary tract, and urinary tract. This study was designed to determine the penetrance of colorectal and extracolonic tumors in HNPCC mutation carriers. Forty-nine patients (22 females and 27 males) were identified with an MSH2 germline mutation, and 56 patients (28 females and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphatases
Share to Age Factors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Carrier Proteins

Share to DNA-Binding Proteins

Share to DNA Repair

Share to Follow-Up Studies

Share to Genotype

Share to Heterozygote

Source

Identifiers

PMID: 9841970
DOI: 10.1016/s1091-255x(98)80105-4

Genes

MSH2
MLH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cumulative incidence of colorectal and extracolonic cancers in MLH1 and MSH2 mutation carriers of hereditary nonpolyposis colorectal cancer.PMID 9841970Read ↗

Colorectal and extracolonic cancer variations in MLH1/MSH2 hereditary nonpolyposis colorectal cancer kindreds and the general population.Semantic proximity Read ↗

MSH2 mutation carriers are at higher risk of cancer than MLH1 mutation carriers: a study of hereditary nonpolyposis colorectal cancer families.Semantic proximity Read ↗

The risk of extra-colonic, extra-endometrial cancer in the Lynch syndrome.Semantic proximity Read ↗

Cancer Risks for PMS2-Associated Lynch Syndrome.Semantic proximity Read ↗

Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome DatabaseSemantic proximity Read ↗

Cancer spectrum in DNA mismatch repair gene mutation carriers: results from a hospital based Lynch syndrome registry.Semantic proximity Read ↗

Cancer Risks for<i>MLH</i><i>1</i>and<i>MSH</i><i>2</i>Mutation CarriersSemantic proximity Read ↗

Penetrance of colorectal cancer among MLH1/MSH2 carriers participating in the colorectal cancer familial registry in OntarioSemantic proximity Read ↗

Cancer-risk by family history and mismatch-repair mutation in Lynch syndrome.Semantic proximity Read ↗

Universal screening for Lynch syndrome in endometrial cancers: frequency of germline mutations and identification of patients with Lynch-like syndrome.Semantic proximity Read ↗

Increased risk for hereditary nonpolyposis colorectal cancer-associated synchronous and metachronous malignancies in patients with microsatellite instability-positive endometrial carcinoma lacking MLH1 promoter methylation.Semantic proximity Read ↗

Cumulative lifetime incidence of extracolonic cancers in Lynch syndrome: a report of 121 families with proven mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.