Colorectal and extracolonic cancer variations in MLH1/MSH2 hereditary nonpolyposis colorectal cancer kindreds and the general population.

doi:10.1007/BF02235755

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Article

Colorectal and extracolonic cancer variations in MLH1/MSH2 hereditary nonpolyposis colorectal cancer kindreds and the general population.

Diseases of the colon and rectum - 1 Apr 1998

Lin K M, Shashidharan M, Ternent C A, Thorson A G, Blatchford G J, Christensen M A, Lanspa S J, Lemon S J, Watson P, Lynch H T

Abstract excerpt

PURPOSE: This clinical case review aimed to identify phenotypic variations in colorectal and extracolonic cancer expression between hereditary nonpolyposis colorectal cancer (HNPCC) families with MLH1 and MSH2 germline mutations and the general population. METHODS: Colorectal cancer onset and sit...

Topics

Adaptor Proteins, Signal Transducing
Adult
Age of Onset
Aged
Carrier Proteins
Colorectal Neoplasms
Colorectal Neoplasms, Hereditary Nonpolyposis
DNA Repair
DNA-Binding Proteins
Female
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Germ-Line Mutation

Humans

Incidence

Male

Middle Aged

MutL Protein Homolog 1

MutS Homolog 2 Protein

Source

Open in PubMed

Identifiers

PMID: 9559626
DOI: 10.1007/BF02235755

Genes

MSH2
MLH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9559626-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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