Lower incidence of colorectal cancer and later age of disease onset in 27 families with pathogenic MSH6 germline mutations compared with families with MLH1 or MSH2 mutations: the German Hereditary Nonpolyposis Colorectal Cancer Consortium.

doi:10.1200/JCO.2004.02.033

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Article

Lower incidence of colorectal cancer and later age of disease onset in 27 families with pathogenic MSH6 germline mutations compared with families with MLH1 or MSH2 mutations: the German Hereditary Nonpolyposis Colorectal Cancer Consortium.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 15 Nov 2004

Plaschke Jens, Engel Christoph, Krüger Stefan, Holinski-Feder Elke, Pagenstecher Constanze, Mangold Elisabeth, Moeslein Gabriela, Schulmann Karsten, Gebert Johannes, von Knebel Doeberitz Magnus, Rüschoff Josef, Loeffler Markus, Schackert Hans K

Abstract excerpt

PURPOSE: The aim of the study was the analysis of the involvement and phenotypic manifestations of MSH6 germline mutations in families suspected of hereditary nonpolyposis colorectal cancer (HNPCC). PATIENTS AND METHODS: Patients were preselected among 706 families by microsatellite instability, immunohistochemistry, and/or exclusion of MLH1 or MSH2 mutations and were subjected to MSH6 mutation analysis. Clinical...

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Identifiers

PMID: 15483016
DOI: 10.1200/JCO.2004.02.033

Genes

MSH6
MLH1
MSH2

Provenance

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