Article
Adrenergic and endothelin B receptor-dependent hypertension in dopamine receptor type-2 knockout mice.
Hypertension (Dallas, Tex. : 1979) - 1 Sept 2001
Li X X, Bek M, Asico L D, Yang Z, Grandy D K, Goldstein D S, Rubinstein M, Eisner G M, Jose P A
Abstract excerpt
Polymorphism of the dopamine receptor type-2 (D(2)) gene is associated with essential hypertension. To assess whether D(2) receptors participate in regulation of blood pressure (BP), we studied mice in which the D(2) receptor was disrupted. In anesthetized mice, systolic and diastolic BPs (in millimeters of mercury) were higher in D(2) homozygous and heterozygous mutant mice than in D(2)+/+ littermates. BP after...
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