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Article

Trp(56) of rac1 specifies interaction with a subset of guanine nucleotide exchange factors.

The Journal of biological chemistry - 14 Dec 2001

Gao Y, Xing J, Streuli M, Leto T L, Zheng Y

Abstract excerpt

Signaling specificity of Rho GTPase pathways is achieved in part by selective interaction between members of the Dbl family guanine nucleotide exchange factors (GEFs) and their Rho GTPase substrates. For example, Trio, GEF-H1, and Tiam1 are a subset of GEFs that specifically activate Rac1 but not the closely related Cdc42. The Rac1 specificity of these GEFs appears to be governed by Rac1-GEF binding interaction....

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Identifiers

PMID: 11595749
DOI: 10.1074/jbc.M108865200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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