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Article

Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1.

Nature - 7 Dec 2000

Worthylake D K, Rossman K L, Sondek J

Abstract excerpt

The principal guanine nucleotide exchange factors for Rho family G proteins contain tandem Dbl-homology (DH) and pleckstrin-homology (PH) domains that catalyse nucleotide exchange and the activation of G proteins. Here we have determined the crystal structure of the DH and PH domains of the T-lymphoma invasion and metastasis factor 1 (Tiam1) protein in complex with its cognate Rho family G protein, Rac1. The two...

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Source

Identifiers

PMID: 11130063
DOI: 10.1038/35047014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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