Article
Molecular basis for Rac1 recognition by guanine nucleotide exchange factors.
Nature structural biology - 1 Dec 2001
Karnoub A E, Worthylake D K, Rossman K L, Pruitt W M, Campbell S L, Sondek J, Der C J
Abstract excerpt
Rho GTPases are activated by a family of guanine nucleotide exchange factors (GEFs) known as Dbl family proteins. The structural basis for how GEFs recognize and activate Rho GTPases is presently ill defined. Here, we utilized the crystal structure of the DH/PH domains of the Rac-specific GEF Tiam1 in complex with Rac1 to determine the structural elements of Rac1 that regulate the specificity of this interaction....
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