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Article

Rational design and characterization of a Rac GTPase-specific small molecule inhibitor.

Proceedings of the National Academy of Sciences of the United States of America - 18 May 2004

Gao Yuan, Dickerson J Bradley, Guo Fukun, Zheng Jie, Zheng Yi

Abstract excerpt

The signaling pathways mediated by Rho family GTPases have been implicated in many aspects of cell biology. The specificity of the pathways is achieved in part by the selective interaction between Dbl family guanine nucleotide exchange factors (GEFs) and their Rho GTPase substrates. Here, we report a first-generation small-molecule inhibitor of Rac GTPase targeting Rac activation by GEF. The chemical compound...

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Identifiers

PMID: 15128949
DOI: 10.1073/pnas.0307512101
PMCID: PMC419655

Genes

PAK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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