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Article

Mechanisms of guanine nucleotide exchange and Rac-mediated signaling revealed by a dominant negative trio mutant.

The Journal of biological chemistry - 30 Jan 2004

Debreceni Balazs, Gao Yuan, Guo Fukun, Zhu Kejin, Jia Baoqing, Zheng Yi

Abstract excerpt

Rho family GTPases play important roles in a variety of cellular processes, including actin cytoskeleton reorganization, transcription activation, and DNA synthesis. Dominant negative mutants of Rho GTPases, such as T17NRac1, that block the endogenous Rho protein activation by sequestering upstre...

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PMID: 14597635
DOI: 10.1074/jbc.M308282200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14597635-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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