Article
The molecular basis of RhoA specificity in the guanine nucleotide exchange factor PDZ-RhoGEF.
The Journal of biological chemistry - 27 Oct 2006
Oleksy Arkadiusz, Opaliński Łukasz, Derewenda Urszula, Derewenda Zygmunt S, Otlewski Jacek
Abstract excerpt
The Dbl homology nucleotide exchange factors (GEFs) activate Rho family cytosolic GTPases in a variety of physiological and pathophysiological events. These signaling molecules typically act downstream of tyrosine kinase receptors and often facilitate nucleotide exchange on more than one member of the Rho GTPase superfamily. Three unique GEFs, i.e. p115, PDZ-RhoGEF, and LARG, are activated by the G-protein...
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