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Article

Sensitizing anthrax lethal toxin-resistant macrophages to lethal toxin-induced killing by tumor necrosis factor-alpha.

The Journal of biological chemistry - 28 Feb 2003

Kim Sung O, Jing Qing, Hoebe Kasper, Beutler Bruce, Duesbery Nicholas S, Han Jiahuai

Abstract excerpt

Macrophages from different inbred mouse strains exhibit striking differences in their sensitivity to anthrax lethal toxin (LeTx)-induced cytolysis. Although LeTx-induced cytolysis of macrophages plays an important role in the outcome of anthrax infection, the sensitivity of macrophages in vitro does not correlate with in vivo susceptibility to infection of Bacillus anthracis. This divergence suggests that...

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Identifiers

PMID: 12488448
DOI: 10.1074/jbc.M209279200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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