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Article

ZW10 helps recruit dynactin and dynein to the kinetochore.

The Journal of cell biology - 10 Aug 1998

Starr D A, Williams B C, Hays T S, Goldberg M L

Abstract excerpt

Mutations in the Drosophila melanogaster zw10 gene, which encodes a conserved, essential kinetochore component, abolish the ability of dynein to localize to kinetochores. Several similarities between the behavior of ZW10 protein and dynein further support a role for ZW10 in the recruitment of dynein to the kinetochore: (a) in response to bipolar tension across the chromosomes, both proteins mostly leave the...

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Identifiers

PMID: 9700164
DOI: 10.1083/jcb.142.3.763
PMCID: PMC2148168

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ZW10 helps recruit dynactin and dynein to the kinetochore.PMID 9700164Read ↗

Kinetochore dynein generates a poleward pulling force to facilitate congression and full chromosome alignment.Semantic proximity Read ↗

The ZW10 and Rough Deal checkpoint proteins function together in a large, evolutionarily conserved complex targeted to the kinetochore.Semantic proximity Read ↗

Determinants of Drosophila zw10 protein localization and function.Semantic proximity Read ↗

Bipolar spindle attachments affect redistributions of ZW10, a Drosophila centromere/kinetochore component required for accurate chromosome segregation.Semantic proximity Read ↗

Zwilch, a new component of the ZW10/ROD complex required for kinetochore functions.Semantic proximity Read ↗

Rough deal and Zw10 are required for the metaphase checkpoint in Drosophila.Semantic proximity Read ↗

A maternal effect rough deal mutation suggests that multiple pathways regulate Drosophila RZZ kinetochore recruitment.Semantic proximity Read ↗

Stable hZW10 kinetochore residency, mediated by hZwint-1 interaction, is essential for the mitotic checkpoint.Semantic proximity Read ↗

The Drosophila l(1)zw10 gene product, required for accurate mitotic chromosome segregation, is redistributed at anaphase onset.Semantic proximity Read ↗

The rate of poleward chromosome motion is attenuated in Drosophila zw10 and rod mutants.Semantic proximity Read ↗

Phosphorylation regulates targeting of cytoplasmic dynein to kinetochores during mitosis.Semantic proximity Read ↗

Conservation of the centromere/kinetochore protein ZW10.Semantic proximity Read ↗

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