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Article

Determinants of Drosophila zw10 protein localization and function.

Journal of cell science - 1 Apr 1994

Williams B C, Goldberg M L

Abstract excerpt

We have examined several issues concerning how the Drosophila l(1)zw10 gene product functions to ensure proper chromosome segregation. (a) We have found that in zw10 mutant embryos and larval neuroblasts, absence of the zw10 protein has no obvious effect on either the congression of chromosomes t...

Topics

Anaphase
Animals
Brain
Carrier Proteins
Cell Cycle Proteins
Chromosomes
Colchicine
Cyclins
DNA
Drosophila Proteins
Drosophila melanogaster
Embryo, Nonmammalian
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Female

Genes, Insect

Genes, Lethal

Insect Hormones

Larva

Source

Identifiers

PMID: 7914521
DOI: 10.1242/jcs.107.4.785

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7914521-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Determinants of Drosophila zw10 protein localization and function.PMID 7914521Read ↗

The Drosophila l(1)zw10 gene product, required for accurate mitotic chromosome segregation, is redistributed at anaphase onset.Semantic proximity Read ↗

Bipolar spindle attachments affect redistributions of ZW10, a Drosophila centromere/kinetochore component required for accurate chromosome segregation.Semantic proximity Read ↗

Conservation of the centromere/kinetochore protein ZW10.Semantic proximity Read ↗

ZW10 helps recruit dynactin and dynein to the kinetochore.Semantic proximity Read ↗

The ZW10 and Rough Deal checkpoint proteins function together in a large, evolutionarily conserved complex targeted to the kinetochore.Semantic proximity Read ↗

Zwilch, a new component of the ZW10/ROD complex required for kinetochore functions.Semantic proximity Read ↗

Rough deal and Zw10 are required for the metaphase checkpoint in Drosophila.Semantic proximity Read ↗

Kinetochore dynein generates a poleward pulling force to facilitate congression and full chromosome alignment.Semantic proximity Read ↗

A maternal effect rough deal mutation suggests that multiple pathways regulate Drosophila RZZ kinetochore recruitment.Semantic proximity Read ↗

The rate of poleward chromosome motion is attenuated in Drosophila zw10 and rod mutants.Semantic proximity Read ↗

Mutations in the essential spindle checkpoint gene bub1 cause chromosome missegregation and fail to block apoptosis in Drosophila.Semantic proximity Read ↗

Stable hZW10 kinetochore residency, mediated by hZwint-1 interaction, is essential for the mitotic checkpoint.Semantic proximity Read ↗

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