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Article

The Drosophila l(1)zw10 gene product, required for accurate mitotic chromosome segregation, is redistributed at anaphase onset.

The Journal of cell biology - 1 Aug 1992

Williams B C, Karr T L, Montgomery J M, Goldberg M L

Abstract excerpt

Mutations in the gene l(1)zw10 disrupt the accuracy of chromosome segregation in a variety of cell types during the course of Drosophila development. Cytological analysis of mutant larval brain neuroblasts shows very high levels of aneuploid cells. Many anaphase figures are aberrant, the most frequent abnormality being the presence of lagging chromosomes that remain in the vicinity of the metaphase plate when the...

Topics

Amino Acid Sequence
Anaphase
Aneuploidy
Animals
Base Sequence
Brain
Cell Cycle Proteins
Chromatids
Drosophila Proteins
Drosophila melanogaster
Insect Hormones

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Larva

Mitosis

Molecular Sequence Data

Mutation

Phenotype

Source

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Identifiers

PMID: 1339459
DOI: 10.1083/jcb.118.4.759
PMCID: PMC2289567

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1339459-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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The Drosophila l(1)zw10 gene product, required for accurate mitotic chromosome segregation, is redistributed at anaphase onset.PMID 1339459Read ↗

Determinants of Drosophila zw10 protein localization and function.Semantic proximity Read ↗

Bipolar spindle attachments affect redistributions of ZW10, a Drosophila centromere/kinetochore component required for accurate chromosome segregation.Semantic proximity Read ↗

Conservation of the centromere/kinetochore protein ZW10.Semantic proximity Read ↗

Rough deal and Zw10 are required for the metaphase checkpoint in Drosophila.Semantic proximity Read ↗

The ZW10 and Rough Deal checkpoint proteins function together in a large, evolutionarily conserved complex targeted to the kinetochore.Semantic proximity Read ↗

ZW10 helps recruit dynactin and dynein to the kinetochore.Semantic proximity Read ↗

Zwilch, a new component of the ZW10/ROD complex required for kinetochore functions.Semantic proximity Read ↗

Mutations in the essential spindle checkpoint gene bub1 cause chromosome missegregation and fail to block apoptosis in Drosophila.Semantic proximity Read ↗

Heterochromatin protein 1 is required for correct chromosome segregation in Drosophila embryos.Semantic proximity Read ↗

Genetic and molecular analysis of wings apart-like (wapl), a gene controlling heterochromatin organization in Drosophila melanogaster.Semantic proximity Read ↗

Recapitulation of the Roberts syndrome cellular phenotype by inhibition of INCENP, ZWINT-1 and ZW10 genes.Semantic proximity Read ↗

A maternal effect rough deal mutation suggests that multiple pathways regulate Drosophila RZZ kinetochore recruitment.Semantic proximity Read ↗

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