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Article

FLT3 internal tandem duplication mutations in adult acute myeloid leukaemia define a high-risk group.

British journal of haematology - 1 Oct 2000

Abu-Duhier F M, Goodeve A C, Wilson G A, Gari M A, Peake I R, Rees D C, Vandenberghe E A, Winship P R, Reilly J T

Abstract excerpt

Genomic DNA from 106 cases of adult de novo acute myeloid leukaemia (AML) was screened by polymerase chain reaction (PCR) and gel electrophoresis for FLT3 internal tandem duplication (ITD) mutations within the juxtamembrane (JM) domain. FLT3 mutations were detected in 14 cases (13.2%) and occurred in FAB types M1 (4 out of 14 cases), M3 (1 out of 10 cases), M4 (5 out of 37 cases) and M5 (4 out of 11 cases)....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11091200
DOI: 10.1046/j.1365-2141.2000.02317.x

Genes

FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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