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Targeting FLT3 mutations in AML: review of current knowledge and evidence

16 Jan 2019

Abstract excerpt

Genomic investigations of acute myeloid leukemia (AML) have demonstrated that several genes are recurrently mutated, leading to new genomic classifications, predictive biomarkers, and new therapeutic targets. Mutations of the FMS-like tyrosine kinase 3 (FLT3) gene occur in approximately 30% of all AML cases, with the internal tandem duplication (ITD) representing the most common type of FLT3 mutation (FLT3-ITD;...

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PMID: 30651634
DOI: 10.1038/s41375-018-0357-9

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