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Article

Ever since Knudson.

Trends in genetics : TIG - 1 Oct 2001

Devilee P, Cleton-Jansen A M, Cornelisse C J

Abstract excerpt

Many publications have documented loss of heterozygosity (LOH) on many different chromosomes in a wide variety of tumours, implicating the existence of multiple tumour suppressor genes (TSGs). Knudson's two-hit hypothesis predicts that these LOH events are the second step in the inactivation of both alleles of a TSG. However, to date the number of TSGs identified that are inactivated mainly at the somatic level...

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Identifiers

PMID: 11585662
DOI: 10.1016/s0168-9525(01)02416-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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