Article
Tumor suppressor genetics.
Carcinogenesis - 1 Dec 2005
Payne Shannon R, Kemp Christopher J
Abstract excerpt
The observation that mutations in tumor suppressor genes can have haploinsufficient, as well as gain of function and dominant negative, phenotypes has caused a reevaluation of the 'two-hit' model of tumor suppressor inactivation. Here we examine the history of haploinsufficiency and tumor suppressors in order to understand the origin of the 'two-hit' dogma. The two-hit model of tumor suppressor gene inactivation...
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